Clinical Profile and Health Disparities in a Multiethnic Cohort of Patients With Hypertrophic Cardiomyopathy

Background: Clinical studies of hypertrophic cardiomyopathy are over-represented by individuals European ethnicity, with less known about other ethnic groups. We investigated differences between patients in a multiethnic Australian population. Methods: performed retrospective cohort study 836 unrelated probands attending specialized clinic 2002 and 2020. Major groups were (n=611), East Asian (n=75), South (n=58), Middle Eastern North African (n=68). The minor ethnicity Oceanian (n=9), People the Americas (n=7), (n=8). One-way ANOVA Dunnett post hoc test Bonferroni adjustment performed. Results: Mean age major was 54.9±16.9 years, 527 (65%) male. Using group as control, had lower body mass index (29 versus 25 kg/m 2 , P <0.0001). Asians prevalence atrial fibrillation (10% 31%, =0.024). more likely to have apical hypertrophy (23% 6%, <0.0001) present left ventricular outflow tract obstruction (46% 34%, =0.0003). undergo genetic testing (55% 85%, or an implantable cardioverter-defibrillator implanted (19% 36%, =0.037). causative variant gene than MYBPC3 MYH7 whereas highest rates variants uncertain significance (27% 21%, Conclusions: There few clinical based on but importantly, we identify health disparities relating access use. Unless addressed, these gaps will widen move towards precision-medicine–based care cardiomyopathy.